Therapeutic potential of yeast killer toxin-like antibodies and mimotopes
| Autor: | Luciano Polonelli, Antonella Salati, Stefania Conti, Walter Magliani, Simona Vaccari, Domenico Leonardo Maffei, Lara Ravanetti |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.drug_class
Molecular Sequence Data Antibiotics Biology medicine.disease_cause Monoclonal antibody Applied Microbiology and Biotechnology Microbiology Pichia law.invention law Candida albicans medicine Humans Amino Acid Sequence Receptor Antibodies Fungal Molecular Mimicry Vaccination Candidiasis Immunization Passive Antibodies Monoclonal General Medicine Mycotoxins biology.organism_classification Virology Killer Factors Yeast Antibodies Anti-Idiotypic Molecular mimicry Monoclonal biology.protein Recombinant DNA Antibody |
| Zdroj: | FEMS Yeast Research. 5:11-18 |
| ISSN: | 1567-1356 |
| DOI: | 10.1016/j.femsyr.2004.06.010 |
| Popis: | This review focuses on the potential of yeast killer toxin (KT)-like antibodies (KTAbs), that mimic a wide-spectrum KT through interaction with specific cell wall receptors (KTR) and their molecular derivatives (killer mimotopes), as putative new tools for transdisease anti-infective therapy. KTAbs are produced during the course of experimental and natural infections caused by KTR-bearing micro-organisms. They have been produced by idiotypic vaccination with a KT-neutralizing mAb, also in their monoclonal and recombinant formats. KTAbs and KTAbs-derived mimotopes may exert a strong therapeutic activity against mucosal and systemic infections caused by eukaryotic and prokaryotic pathogenic agents, thus representing new potential wide-spectrum antibiotics. |
| Databáze: | OpenAIRE |
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