Reversible colchicine-induced disruption of amygdaloid function in sodium appetite
| Autor: | Douglas Avrith, Andrew J. Zolovick, John E. Jalowiec |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Sodium media_common.quotation_subject Drinking chemistry.chemical_element Water consumption Antimitotic drug Thirst chemistry.chemical_compound Body Water Formaldehyde Hypovolemia Internal medicine medicine Animals Colchicine media_common Afferent Pathways Appetite Regulation Chemistry General Neuroscience Appetite Water-Electrolyte Balance Amygdala medicine.disease Rats Endocrinology medicine.symptom Hyponatremia |
| Zdroj: | Brain Research Bulletin. 5:35-39 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(80)90280-4 |
| Popis: | Bilateral injections of the antimitotic drug colchicine into the medial amygdaloid nuclei resulted in a dissociation of the normally concurrent sodium appetite and water thirst in rats following formalin-induced hypovolemia and hyponatremia. While control rats drank the normally aversive sodium solution as well as water after formalin injection, colchicine-treated animals failed to ingest the sodium solution but did consume the expected amount of water in order to compensate for hypovolemia. Sodium consumption, but not water consumption, remained significantly depressed in the colchicine-treated rats when they were challenged again with formalin 11 days but not 20 days after amygdaloid injections. The latter result suggested complete recovery from the colchicine-induced amygdaloid dysfunction. This study indicates that colchicine may serve as a potentially useful technique for producing reversible lesions of known duration for the assessment of brain-behavior relationships. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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