(-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats
| Autor: | Munetaka Nokubo, Maria-Cristina Carrillo, Kenichi Kitani, Setsuko Kanai |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Striatum General Biochemistry Genetics and Molecular Biology Superoxide dismutase Isomerism Reference Values Internal medicine Selegiline medicine Animals General Pharmacology Toxicology and Pharmaceutics Young male chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase General Medicine Catalase Corpus Striatum Rats Inbred F344 Rats Kinetics medicine.anatomical_structure Endocrinology Enzyme chemistry biology.protein medicine.drug |
| Zdroj: | Life sciences. 48(6) |
| ISSN: | 0024-3205 |
| Popis: | Daily s.c. injection of (−)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was also increased significantly by deprenyl treatment. The results confirmed the previous findings of Knoll (1) on SOD activity and furthermore provided evidence that the activity of catalase is also significantly induced by the drug, which was not found in the previous study (1). |
| Databáze: | OpenAIRE |
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