The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
| Autor: | Nils Lindefors, Jan Bergström, Christian Rück, Tina B. Lonsdorf, Gerhard Andersson, Arne Öhman, Martin Schalling |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype lcsh:RC435-571 medicine.medical_treatment Exposure therapy Implosive Therapy Catechol O-Methyltransferase SAMHÄLLSVETENSKAP behavioral disciplines and activities law.invention Extinction Psychological Methionine Randomized controlled trial SOCIAL SCIENCES law lcsh:Psychiatry mental disorders medicine Humans Psychiatry Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Cognitive Behavioral Therapy Panic disorder Panic Valine Extinction (psychology) Fear Middle Aged medicine.disease humanities Cognitive behavioral therapy Psychiatry and Mental health Treatment Outcome Cognitive therapy Anxiety Panic Disorder Female medicine.symptom Psychology Clinical psychology Research Article |
| Zdroj: | BMC Psychiatry, Vol 10, Iss 1, p 99 (2010) BMC Psychiatry |
| ISSN: | 1471-244X |
| Popis: | Background: Cognitive behavioral therapy (CBT) represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fear responses. We have recently demonstrated that the ability to extinguish learned fear responses is associated with a functional genetic polymorphism (COMTval158met) in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting. Methods: We tested a possible effect of the COMTval158met polymorphism on the efficacy of CBT, in particular exposure-based treatment modules, in a sample of 69 panic disorder patients. Results: We present evidence that panic patients with the COMTval158met met/met genotype may profit less from (exposure-based) CBT treatment methods as compared to patients carrying at least one val-allele. No association was found with the 5-HTTLPR/rs25531 genotypes which is presented as additional material. Conclusions: We were thus able to transfer findings on the effect of the COMTval158met polymorphism from an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Limitations of the study as well as possible clinical implications are discussed. Original Publication:Tina B Lonsdorf, Christian Ruck, Jan Bergstrom, Gerhard Andersson, Arne Ohman, Nils Lindefors and Martin Schalling, The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder, 2010, BMC PSYCHIATRY, (10), 99.http://dx.doi.org/10.1186/1471-244X-10-99Licensee: BioMed Centralhttp://www.biomedcentral.com/ |
| Databáze: | OpenAIRE |
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