Plasma and breast milk vitamin A as indicators of vitamin A status in pregnant women
| Autor: | Paolo G. Miotti, Taha E. Taha, Ward Eisinger, Richard D. Semba, Donald R. Hoover, Laban Mtimavalye, Robin L. Broadhead, Newton Kumwenda, John D. Chiphangwi |
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| Rok vydání: | 2001 |
| Předmět: |
Vitamin
Adult medicine.medical_specialty Malawi Endocrinology Diabetes and Metabolism Mammary gland Medicine (miscellaneous) Physiology Nutritional Status HIV Infections Breast milk chemistry.chemical_compound Pregnancy Internal medicine Medicine Humans Pregnancy Complications Infectious Vitamin A Nutrition and Dietetics Milk Human business.industry Vitamin A Deficiency Retinol Retinol Equivalent General Medicine Orosomucoid medicine.disease Endocrinology medicine.anatomical_structure C-Reactive Protein chemistry Blood chemistry Gestation Female business Biomarkers |
| Zdroj: | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 70(6) |
| ISSN: | 0300-9831 |
| Popis: | Breast milk vitamin A is not well characterized as an indicator of vitamin A status in women with infections. A controlled trial of vitamin A, 3 mg retinol equivalent/day, was conducted among 697 pregnant women with human immunodeficiency virus (HIV) infection in Malawi which allowed comparison of plasma versus breast milk vitamin A as indicators of vitamin A status. Retinol concentrations were measured in plasma at baseline (18–28 weeks) and 38 weeks gestation and breast milk at 6 weeks post-partum. Plasam a1-acid glycoprotein (AGP) and C-reactive protein (CRP) were measured at baseline. Plasma retinol (geometric mean, SD) at 38 weeks was 0.72 (0.44, 1.18) and 0.61 (0,38, 0.98) mmol/L (P < 0.0002) and breast milk retinol was 1.32 (0.71, 2.43) and 0.95 (0.49, 1.82) mmol/L (P < 0.0001) in vitamin A and placebo groups, respectively. Women with elevated acute phase protein (AGP > 1 gm/L and/or CRP > 5 mg/L) at baseline who received vitamin A had significantly higher plasma and breast milk vitamin A at follow-up compared with placebo, Elevated acute phase proteins did not distinguish women with low body stores of vitamin A. Breast rnilk retinol appears to be a better indicator of vitamin A status than plasma retinol in women with infections. |
| Databáze: | OpenAIRE |
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