YM-24074, a New Peptide Antibiotic. II. Structural Elucidation
| Autor: | Tsutomu Sato, Tatsuhiro Tokunaga, Yukihiro Takebayashi, Teruaki Ozasa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Magnetic Resonance Spectroscopy biology medicine.drug_class Chemistry Stereochemistry Chemical structure Antibiotics Molecular Conformation Peptide Nuclear magnetic resonance spectroscopy Anti-Bacterial Agents Pyridazines Enzyme Enzyme inhibitor Microbial collagenase Drug Discovery medicine biology.protein Peptides Antibacterial agent |
| Zdroj: | The Journal of Antibiotics. 49:811-814 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.49.811 |
| Popis: | YM-24074 (formerly called YL-01869P) is a new antibiotic and type I collagenase inhibitor. The structure of this compound was elucidated by spectroscopic analysis and confirmed by acid degradation to be N-(1"-acetyl-3"-methylbutyl)-2- [2'-[(N-hydroxycarbamoyl)methyl]heptanoyl]-hexahydropyrid azine-3-carboxamide. The stereochemistry of two of three chiral centers was determined by degradation products to be 3S, 2'R. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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