Autonomic and Enteric Nervous System Dysfunction May Play a Role in Hyperemesis Gravidarum
| Autor: | Caroline A. Riely, Robert Egerman, Thomas L. Abell, Neeta G. Nayak, James G. Karas, Sergio Cardoso, David C. Shaver, Naeem Aslam, Joy Hughes, Hani Rashed, Babajide O. Familoni, Alan Wallstedt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Weight loss Hyperemesis gravidarum Nausea business.industry Adrenergic medicine.disease Gastroenterology Autonomic nervous system Endocrinology Pregnancy Internal medicine Nausea and vomiting medicine Vomiting Cholinergic Enteric nervous system Original Article medicine.symptom business Vasoconstriction |
| Zdroj: | Gastroenterology Research |
| ISSN: | 1918-2813 1918-2805 |
| Popis: | Background: Nausea and vomiting, seen in 70-85% of all pregnancies, becomes intractable in hyperemesis gravidarum (HG). We aimed to investigate the relationship between HG and autonomic nervous system functioning and gastric electrical activity. Methods: Twenty-seven pregnant patients, 21 with HG and six normal, were studied with sympathetic adrenergic; percent vasoconstriction (%VC) and postural adjustment ratio (PAR); parasympathetic vagal cholinergic functions by R-to-R intervals (RRIs), a total autonomic score; and enteric nervous system measured by electrogastrography (EGG). Results: Significant differences were found in parasympathetic measures (RRI for HG 29.98 ± 2.95 vs. control 40.91 ± 2.38, P < 0.05); sympathetic PAR was significantly lower in patients (PAR for HG 24.5 ± 5.0 vs. 67.6 ± 11.4 for controls, P < 0.01); mean total autonomic score was significantly lower in HG (131.75 ± 9.61 vs. 196.87 ± 12.8, P < 0.05). EGG results were borderline different (normal < 3.3, HG 3.4 vs. controls 3.0, P = 0.07). Conclusion: Autonomic and enteric nervous system dysfunction may play a role in the pathophysiology of HG. Gastroenterol Res. 2015;8(1):153-156 doi: http://dx.doi.org/10.14740/gr632w |
| Databáze: | OpenAIRE |
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