A Study on Serum Carotenoid Levels in Breast Cancer Patients of Indian Women in Chennai (Madras), India
| Autor: | Koji Suzuki, Ryuichiro Sasaki, Viswanathan Shanta, Kesavan C. Gajalakshmi, Yoshinori Ito |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Lutein Estrone Epidemiology India Physiology Breast Neoplasms Xanthophylls Antioxidants chemistry.chemical_compound Lycopene Breast cancer Zeaxanthins Vegetables Anticarcinogenic Agents Humans Vitamin E Medicine Vitamin A Chromatography High Pressure Liquid Cryptoxanthins Aged Aged 80 and over Gynecology business.industry Case-control study food and beverages Cancer Estriol Feeding Behavior General Medicine Middle Aged beta Carotene medicine.disease Carotenoids Menopause chemistry Case-Control Studies Fruit Female Cryptoxanthin business |
| Zdroj: | Journal of Epidemiology. 9:306-314 |
| ISSN: | 0917-5040 |
| DOI: | 10.2188/jea.9.306 |
| Popis: | Two-hundred and six breast cancer cases were histologically confirmed breast cancer diagnoses at the Cancer Institute in Chennai (Madras), India. One-hundred and fifty hospital controls were patients who had cancer at any site other than breast and gynecological organs, and 61 healthy controls were persons accompanying patients in the Cancer Institute. Serum levels of carotenoids such as beta-carotene, lycopene, cryptoxanthin, and zeaxanthin & lutein were determined by HPLC. Serum levels of total carotenes and total carotenoids including beta-carotene, which reflects food intake of colored vegetables and fruits and has a protective role for certain sites of cancer, were significantly lower among breast cancer cases and hospital controls compared to healthy controls, especially in post-menopausal women. Serum carotenoid levels appeared to change with menopausal status. Serum beta-carotene levels tended to be lower among breast cancer cases than among hospital controls in premenopausal women. Serum xanthophyll levels were significantly lower among breast cancer cases than among healthy controls in post-menopausal women, but not in premenopausal women. Serum levels of retinol and alpha-tocopherol among breast cancer cases were not significantly different from those in post-menopausal healthy controls, but were higher than those in hospital controls. Serum estrone levels were significantly higher among breast cancer cases than among healthy controls, but serum levels of estradiol and estriol were not. In conclusion, Indian women with cancer of breast or of other sites might have low intake of green-yellow vegetables rich in fiber and carotenoids such as beta-carotene and zeaxanthin & lutein. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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