Helicobacter pylori Eradication in Patients on Long-term Treatment With NSAIDs Reduces the Severity of Gastritis A Randomized Controlled Trial
| Autor: | Matthijs Janssen, J. W. J. Bijlsma, Harry H.M.L. Houben, Willem F. Lems, Helena T.J.I. de Leest, Ben A. C. Dijkmans, Maarten Boers, Mart A F J van de Laar, Ernst J. Kuipers, Elisabeth Bloemena, K.S.S. Steen, Piet J. Kostense |
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| Přispěvatelé: | Faculty of Behavioural, Management and Social Sciences, Gastroenterology and hepatology, Rheumatology, Pathology, Oral and Maxillofacial Surgery / Oral Pathology, Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, CCA - Innovative therapy, Gastroenterology & Hepatology, Hematology, EMGO+ - Lifestyle, Overweight and Diabetes, Clinical Neuropsychology |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Time Factors Gastroenterology Severity of Illness Index Anti-Infective Agents Medicine gastritis histology biology Stomach Anti-Inflammatory Agents Non-Steroidal Nonsteroidal anti-inflammatory drugs Intestinal metaplasia SDG 10 - Reduced Inequalities Middle Aged medicine.anatomical_structure Treatment Outcome METIS-265951 Gastritis Drug Therapy Combination Female medicine.symptom Omeprazole medicine.medical_specialty medicine.drug_class proton pump inhibitor Proton-pump inhibitor macromolecular substances Placebo Helicobacter Infections Atrophy Pharmacotherapy Double-Blind Method IR-71332 Internal medicine Clarithromycin Metronidazole Humans Aged Helicobacter pylori business.industry Amoxicillin medicine.disease biology.organism_classification Anti-Ulcer Agents digestive system diseases Gastric Mucosa business |
| Zdroj: | Journal of clinical gastroenterology, 43(2). Lippincott Williams and Wilkins Journal of Clinical Gastroenterology, 43(2), 140-146. Lippincott Williams and Wilkins de Leest, H T J I, Steen, K S S, Bloemena, E, Lems, W F, Kuipers, E, van der Laar, M C, Bijlsma, J J E, Janssen, M M J, Houben, H H, Kostense, P J, Boers, M & Dijkmans, B A C 2009, ' Helicobacter pylori Eradication in Patients on Long-term Treatment With NSAIDs Reduces the Severity of Gastritis A Randomized Controlled Trial ', Journal of Clinical Gastroenterology, vol. 43, no. 2, pp. 140-146 . https://doi.org/10.1097/MCG.0b013e3181595b40 Journal of Clinical Gastroenterology, 43(2), 140-146. Lippincott Williams & Wilkins |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/MCG.0b013e3181595b40 |
| Popis: | BACKGROUND: Maintenance use of nonsteroidal anti-inflammatory drugs (NSAIDs) is often complicated by gastropathy. In non-NSAID users, eradication of Helicobacter pylori is associated with decreased mucosal inflammation, and may halt the progression to atrophy and intestinal metaplasia, but the continuous use of NSAIDs may interfere with these processes. GOAL: To investigate the effect of H. pylori eradication on gastric mucosal histology during long-term NSAID use, with and without gastroprotective therapy. STUDY: Patients were eligible for inclusion if they were on long-term NSAIDs and were H. pylori-positive on serologic testing. Patients were randomly assigned to either eradication or placebo. Gastritis was assessed according to the updated Sydney classification for activity, chronic inflammation, gastric glandular atrophy, intestinal metaplasia, and H. pylori density. RESULTS: Biopsy specimens were available for histology of 305 patients. Of these, 48% were on chronic gastroprotective medication. Significant less active gastritis, inflammation, and H. pylori density was found in the eradication group compared with the placebo group in both corpus and antrum (P |
| Databáze: | OpenAIRE |
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