Modulation of SK channel trafficking by beta adrenoceptors enhances excitatory synaptic transmission and plasticity in the amygdala
| Autor: | James W. Crane, Petra L. Sedlak, Pankaj Sah, E. S. Louise Faber, John M. Power, Andrew J. Delaney |
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| Rok vydání: | 2008 |
| Předmět: |
Patch-Clamp Techniques
Small-Conductance Calcium-Activated Potassium Channels Green Fluorescent Proteins Long-Term Potentiation Nonsynaptic plasticity Enzyme Activators Neurotransmission Transfection Membrane Potentials SK channel Adrenergic Agents Organ Culture Techniques Synaptic augmentation Metaplasticity Receptors Adrenergic beta Animals Enzyme Inhibitors Rats Wistar Egtazic Acid Chemistry General Neuroscience Pyramidal Cells Excitatory Postsynaptic Potentials Long-term potentiation Articles Amygdala Electric Stimulation Endocytosis Rats Protein Transport Synaptic fatigue Animals Newborn Apamin Synaptic plasticity Neuroscience Excitatory Amino Acid Antagonists |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(43) |
| ISSN: | 1529-2401 |
| Popis: | Emotionally arousing events are particularly well remembered. This effect is known to result from the release of stress hormones and activation of β adrenoceptors in the amygdala. However, the underlying cellular mechanisms are not understood. Small conductance calcium-activated potassium (SK) channels are present at glutamatergic synapses where they limit synaptic transmission and plasticity. Here, we show that β adrenoceptor activation regulates synaptic SK channels in lateral amygdala pyramidal neurons, through activation of protein kinase A. We show that SK channels are constitutively recycled from the postsynaptic membrane and that activation of β adrenoceptors removes SK channels from excitatory synapses. This results in enhanced synaptic transmission and plasticity. Our findings demonstrate a novel mechanism by which β adrenoceptors control synaptic transmission and plasticity, through regulation of SK channel trafficking, and suggest that modulation of synaptic SK channels may contribute to β adrenoceptor-mediated potentiation of emotional memories. |
| Databáze: | OpenAIRE |
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