Immunohistochemical detection of Mdm2 and p53 in feline mammary gland tumors
| Autor: | Makoto Inoue, Yasuho Taura, Haiyan Wu, Masatoshi Nakano |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
P53 overexpression
Adenoma Pathology medicine.medical_specialty Mammary gland Mammary Neoplasms Animal Biology Adenocarcinoma medicine.disease_cause Cat Diseases medicine Biomarkers Tumor Animals Stage (cooking) General Veterinary Proto-Oncogene Proteins c-mdm2 Immunohistochemistry digestive system diseases medicine.anatomical_structure P53 protein biology.protein Cancer research Cats Mdm2 Female Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | The Journal of veterinary medical science. 68(5) |
| ISSN: | 0916-7250 |
| Popis: | The objective of this study was to evaluate nuclear reactivity of Mdm2 and p53 proteins by immunohistochemical means in feline mammary gland tumors; 12 adenomas which included 6 adenomatous lesions obtained from the tissue adjacent to adenocarcinomas, and 22 adenocarcinomas. Seven adenomas and 18 adenocarcinomas showed moderate or marked Mdm2 reactivity. Sixteen adenocarcinomas showed moderate to marked p53 reactivity, but 9 adenomas showed none. Discordant Mdm2 overexpression was found in 5 adenomas and 3 adenocarcinomas, although co-overexpression of Mdm2 and p53 was found in 15 adenocarcinomas. These results suggest that nuclear overexpression of Mdm2 is present in the tumors of early stage without p53 overexpression and related to feline mammary gland tumorigenesis. Nuclear overexpression of p53 is more frequent in adenocarcinomas, but not in adenomas. |
| Databáze: | OpenAIRE |
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