| Autor: |
Javier I. Ottaviani, Reedmond Y. Fong, Gina Borges, Jennifer Kimball, Jodi L. Ensunsa, Valentina Medici, L. Kirsty Pourshahidi, Emma Kane, Karen Ward, Rebecca Durkan, Sara Dobani, Roger Lawther, Gloria O'Connor, Chris I.R. Gill, Hagen Schroeter, Alan Crozier |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Free Radical Biology and Medicine. 196:1-8 |
| ISSN: |
0891-5849 |
| Popis: |
Flavan-3-ols, including the flavan-3-ol monomer (-)-epicatechin, are dietary bioactives known to mediate beneficial cardiovascular effects in humans. Recent studies showed that flavan-3-ols could interact with methylxanthines, evidenced by an increase in flavan-3-ol bioavailability with a concomitant increase in flavan-3-ol intake-mediated vascular effects. This study aimed at elucidating flavan-3-ol-methylxanthine interactions in humans in vivo by evaluating the specific contributions of theobromine and caffeine on flavan-3-ol bioavailability. In ileostomists, the effect of methylxanthines on the efflux of flavan-3-ol metabolites in the small intestine was assessed, a parameter important to an understanding of the pharmacokinetics of flavan-3-ols in humans. In a randomized, controlled, triple cross-over study in volunteers with a functional colon (n = 10), co-ingestion of flavan-3-ols and cocoa methylxanthines, mainly represented by theobromine, increased peak circulatory levels (C |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect