Tissue advanced glycation end products are associated with diastolic function and aerobic exercise capacity in diabetic heart failure patients
| Autor: | Yoran M. Hummel, Marieke H. I. van Ruijven, Suzan Willemsen, Jasper W. L. Hartog, Iwan C. C. van der Horst, Adriaan A. Voors, Dirk J. van Veldhuisen |
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| Přispěvatelé: | Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Cardiovascular Centre (CVC) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty Ventricular Ejection Fraction Diastolic function STRESS Diastole Heart failure Ventricular Function Left VENTRICULAR EJECTION FRACTION MELLITUS Oxygen Consumption Double-Blind Method Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Aerobic exercise Advanced glycation end products Exercise Aerobic capacity Aged Netherlands Ultrasonography Heart Failure Diastolic Exercise Tolerance Ejection fraction CONSEQUENCES business.industry Diabetes VO2 max Stroke Volume SKIN AUTOFLUORESCENCE Middle Aged medicine.disease Multivariate Analysis Disease Progression Exercise Test Linear Models Cardiology RISK-FACTORS Female TRIAL Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Journal of Heart Failure, 13(1), 76-82. Wiley |
| ISSN: | 1388-9842 |
| Popis: | Aims Advanced glycation end products (AGEs) are increased in patients with diabetes and are associated with diastolic dysfunction through the formation of collagen crosslinks in the heart. The association among AGEs, diastolic function, and aerobic capacity in heart failure (HF) patients with and without diabetes is, however, unknown. We therefore studied the association among tissue AGEs, diastolic function, and aerobic capacity in patients with HF with or without diabetes.Methods and results In chronic HF patients (with and without left ventricular systolic dysfunction), tissue AGEs [skin autofluorescence (AF)], diastolic function (echocardiographic mean E' and E/E'), and aerobic capacity [peak oxygen uptake (VO(2)) on cardiopulmonary exercise testing] were obtained. A total of 49 diabetics and 156 non-diabetics were included. Diabetics were older and had more cardiovascular risk factors, but left ventricular ejection fractions (LVEF) were similar. Tissue AGEs were higher in diabetics compared with non-diabetics (2.8 +/- 0.8 vs. 2.3 +/- 0.7 a.u.; P Conclusion Patients with diabetes and HF have similar LVEF but poorer exercise capacity compared with non-diabetic HF patients. Our data suggest that these findings might be explained by the observed association among tissue AGE levels, diastolic function, and exercise capacity. |
| Databáze: | OpenAIRE |
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