Surfactant without intubation in preterm infants with respiratory distress: first multi-center data
| Autor: | Angela Kribs, B. Roth, E. Kattner, W. Göpel, Jens Möller, H. Küster, Christian Wieg, Axel von der Wense, M. Vochem, D. Müller, Werner Nikischin, Hugo Segerer, Christoph Härtel, Egbert Herting, Corinna Gebauer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Birth weight medicine.medical_treatment Gestational Age Cohort Studies Intubation Intratracheal Medicine Humans Infant Very Low Birth Weight Continuous positive airway pressure Prospective Studies Phospholipids Bronchopulmonary Dysplasia Mechanical ventilation Biological Products Respiratory Distress Syndrome Newborn Respiratory distress Continuous Positive Airway Pressure business.industry Infant Newborn Oxygen Inhalation Therapy Gestational age Pulmonary Surfactants Doxapram medicine.disease Survival Analysis Low birth weight Instillation Drug Bronchopulmonary dysplasia Infant Extremely Low Birth Weight Anesthesia Pediatrics Perinatology and Child Health Female medicine.symptom business medicine.drug |
| Zdroj: | Klinische Padiatrie. 222(1) |
| ISSN: | 1439-3824 |
| Popis: | BACKGROUND: Recently in a report of a single center a method has been described to apply surfactant via a thin endotracheal catheter to very low birth weight infants spontaneously breathing with nasal continuous positive airway pressure. We now analyzed available multicenter data. PATIENTS AND METHODS: In a multicenter study investigating genetic risk factors, clinical and outcome data and data of antenatal and postnatal treatment of infants with a birth weight below 1 500 g were prospectively recorded. The measures of infants treated with the new method of surfactant application were compared to those of infants who received standard care. The analysis was restricted to infants with a gestational age below 31 weeks (n=1 541). RESULTS: 319 infants were treated with the new method and 1 222 with standard care. The need for mechanical ventilation during the first 72 h (29% vs. 53%, p |
| Databáze: | OpenAIRE |
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