The critical role of nuclear factor I‐C in tooth development
| Autor: | Jun Wang, Xudong Xie, Chunmei Xu, Lei Zhao, Yafei Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Odontoblast differentiation
Biology Zinc Finger Protein GLI1 Mice stomatognathic system Transforming Growth Factor beta medicine Dentin Animals Humans Cementum Tooth Root General Dentistry Odontoblasts Enamel paint Cell Differentiation Cell biology NFI Transcription Factors stomatognathic diseases Enamel mineralization medicine.anatomical_structure Odontoblast NFIC Otorhinolaryngology visual_art Ameloblast differentiation visual_art.visual_art_medium Odontogenesis |
| Zdroj: | Oral Diseases. 28:2093-2099 |
| ISSN: | 1601-0825 1354-523X |
| Popis: | Objectives Nuclear factor I-C (NFIC) plays a critical role in regulating epithelial-mesenchymal crosstalk during tooth development. However, it remains largely unknown about how NFIC functions in dentin and enamel formation. In the present review, we aim to summarize the most recent discoveries in the field and gain a better understanding of the roles NFIC performs during tooth formation. Subjects and methods Nfic-/- mice exhibit human dentin dysplasia type I (DDI)-like phenotypes signified by enlarged pulp chambers, the presence of short-root anomaly, and failure of odontoblast differentiation. Although loss of NFIC has little effect on molar crown morphology, researchers have detected aberrant microstructures of enamel in the incisors. Recently, accumulating evidence has further uncovered the novel function of NFIC in the process of enamel and dentin formation. Results During epithelial-mesenchyme crosstalk, the expression of NFIC is under the control of SHH-PTCH-SMO-GLI1 pathway. NFIC is closely involved in odontoblast lineage cells proliferation and differentiation, and the maintenance of NFIC protein level in cytoplasm is negatively regulated by TGF-β signaling pathway. In addition, NFIC has mild effect on ameloblast differentiation, enamel mineralization and cementum formation. Conclusions NFIC plays an important role in tooth development and is required for the formation of dentin, enamel as well as cementum. |
| Databáze: | OpenAIRE |
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