Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants

Autor: Provvidenza Damiani, Rosalyn A. Jurjus, Alice Gerges Geagea, Francesca Rappa, Giovanni Tomasello, Margherita Mazzola, Abdo Jurjus, Sahar Al Kattar, Francesco Carini, Angelo Leone, Tarek Bou-Assi
Přispěvatelé: Carini,F, Mazzola,M, Rappa,F, Jurjus,A, Gerges Geagea,A, Al Kattar,S, Bou-Assi,T, Jurjus,R, Damiani,P, Leone,A, Tomasello,G
Rok vydání: 2017
Předmět:
0301 basic medicine
Cancer Research
Carcinogenesis
Settore MED/06 - Oncologia Medica
Colorectal cancer
DNA repair
Cell
Review
Colorectal Neoplasm
medicine.disease_cause
Antioxidants
03 medical and health sciences
0302 clinical medicine
Dysbiosis
Oxidative stress
Animals
Colorectal Neoplasms
Humans
Reactive Oxygen Species
Oxidative Stress
Oncology
Medicine
colorectal cancer
dysbiosis
microbioma
oxodative stress
carcinogenesi
Carcinogenesi
chemistry.chemical_classification
Reactive oxygen species
Animal
business.industry
Oxidative Stre
General Medicine
Colorectal carcinogenesis
medicine.disease
Dysbiosi
Settore MED/18 - Chirurgia Generale
colorectal cancer
dysbiosis
microbioma
oxodative stress
carcinogenesis
030104 developmental biology
medicine.anatomical_structure
Biochemistry
chemistry
030220 oncology & carcinogenesis
Cancer research
Antioxidant
Reactive Oxygen Specie
business
Human
Zdroj: Anticancer Research. 37
ISSN: 1791-7530
0250-7005
DOI: 10.21873/anticanres.11882
Popis: One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.
Databáze: OpenAIRE
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