Whole-Brain Haemodynamic After-Effects of 1-Hz Magnetic Stimulation of the Posterior Superior Temporal Cortex During Action Observation

Autor: Jens Schwarzbach, Guido Barchiesi, Silvia Ubaldi, Luigi Cattaneo, Paolo Ferrari, Carola Arfeller
Rok vydání: 2012
Předmět:
Adult
Male
medicine.medical_treatment
Motion Perception
action observation
apraxia
fMRI
mirror neurons
superior temporal sulcus
transcranial magnetic stimulation
behavioral disciplines and activities
Functional Laterality
Premotor cortex
Cortex (anatomy)
medicine
Humans
Radiology
Nuclear Medicine and imaging
Neuronavigation
Mirror neuron
Visual Cortex
Temporal cortex
Radiological and Ultrasound Technology
medicine.diagnostic_test
musculoskeletal
neural
and ocular physiology
Hemodynamics
Brain
Superior temporal sulcus
Magnetic Resonance Imaging
Temporal Lobe
Oxygen
Transcranial magnetic stimulation
medicine.anatomical_structure
nervous system
Neurology
Female
Neurology (clinical)
Anatomy
Functional magnetic resonance imaging
Psychology
Neuroscience
Photic Stimulation
psychological phenomena and processes
Biological motion
Zdroj: Brain Topography. 26:278-291
ISSN: 1573-6792
0896-0267
Popis: The posterior superior temporal sulcus (pSTS) is active when observing biological motion. We investigated the functional connections of the pSTS node within the action observation network by measuring the after-effect of focal repetitive transcranial magnetic stimulation (rTMS) with whole-brain functional magnetic resonance imaging (fMRI). Participants received 1-Hz rTMS over the pSTS region for 10 min and underwent fMRI immediately after. While scanned, they were shown short video clips of a hand grasping an object (grasp clips) or moving next to it (control clips). rTMS-fMRI was repeated for four consecutive blocks. In two blocks we stimulated the left pSTS region and in the other two the right pSTS region. For each side TMS was applied with an effective intensity (95 % of motor threshold) or with ineffective intensity (50 % of motor threshold). Brain regions showing interactive effects of (clip type) × (TMS intensity) were identified in the lateral temporo-occipital cortex, in the anterior intraparietal region and in the ventral premotor cortex. Remote effects of rTMS were mostly limited to the stimulated hemisphere and consisted in an increase of blood oxygen level-dependent responses to grasp clips compared to control clips. We show that the pSTS occupies a pivotal relay position during observation of goal-directed actions.
Databáze: OpenAIRE
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