PCB153 (2,2′,4,4′,5,5′-hexachlorobiphenyl) differentially affects the VEGF/VEGFR system depending on photoperiod in the ovine choroid plexus
| Autor: | Janina Skipor, Vincent Robert, J. Mlynarczuk, Laurence Dufourny, Jean-Claude Thiéry, Aleksandra Szczepkowska, Christine Lagaraine |
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| Přispěvatelé: | Institute of Animal Reproduction and Food Research, Polska Akademia Nauk (PAN), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Ministry of Science and Higher Education, Poland (Grant no. 258/N-INRA/2008/0), INRA, France (Grant no. WM/N19/INRA/2008), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), European Project: 264103,EC:FP7:REGPOT,FP7-REGPOT-2010-1,REFRESH(2010), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine medicine.medical_specialty [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] Endothelium polychlorinated biphenyls Health Toxicology and Mutagenesis 010501 environmental sciences Biology photoperiod 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Cerebrospinal fluid Internal medicine medicine Animals RNA Messenger 0105 earth and related environmental sciences Messenger RNA Sheep choroid plexus Dose-Response Relationship Drug Estradiol Tight junction vascular endothelial growth factor Public Health Environmental and Occupational Health Brain General Medicine Pollution ewe Vascular endothelial growth factor Vascular endothelial growth factor A Receptors Vascular Endothelial Growth Factor 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Female Choroid plexus Homeostasis |
| Zdroj: | Ecotoxicology and Environmental Safety Ecotoxicology and Environmental Safety, Elsevier, 2016, 124, pp.303-308. ⟨10.1016/j.ecoenv.2015.11.007⟩ Ecotoxicology and Environmental Safety, 2016, 124, pp.303-308. ⟨10.1016/j.ecoenv.2015.11.007⟩ |
| ISSN: | 0147-6513 1090-2414 |
| DOI: | 10.1016/j.ecoenv.2015.11.007⟩ |
| Popis: | Ortho-substituted polychlorinated biphenyls (PCBs) preferentially accumulate in the brain and cerebrospinal fluid (CSF) compared with other PCBs. We previously demonstrated in ewes that an identical dose of PCB153, the most environmentally prevalent congener, resulted in a higher plasma concentration during short days (SD: 1200 pg/ml) than during long days (LD: 200 pg/ml). Moreover, PCB153 treatment only reduced the SD tight junction protein content in the choroid plexus (CP), which was followed by a significant increase of the PCB153 concentration in the CSF. The aim of the present study was to evaluate how PCB153 treatment affects the VEGF/VEGFR system that maintains CSF homoeostasis and CP function. To do so, we collected CPs from ovariectomised, oestradiol-replaced adult ewes maintained under artificial LD or SD and treated them per os with low doses of PCB153 (0.3 mg/kg, 3 times a week for 3 weeks). Exposure to PCB153 significantly affected (P |
| Databáze: | OpenAIRE |
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