Multiple organ dysfunction syndrome in hematopoietic stem cell transplantation
| Autor: | William D. Haire |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Lung Diseases
Pathology medicine.medical_specialty Multiple Organ Failure medicine.medical_treatment Antithrombin III Hepatic Veno-Occlusive Disease Disease Hematopoietic stem cell transplantation Critical Care and Intensive Care Medicine Central Nervous System Diseases Intensive care medicine Humans Interleukin-6 Tumor Necrosis Factor-alpha business.industry Organ dysfunction Hematopoietic Stem Cell Transplantation Hypoxia (medical) medicine.disease Transplantation Logistic Models Platelet transfusion medicine.symptom Multiple organ dysfunction syndrome business Protein C |
| Zdroj: | Critical Care Medicine. 30:S257-S262 |
| ISSN: | 0090-3493 |
| Popis: | Objective: To review the data demonstrating that central nervous system, pulmonary, and hepatic dysfunctions during hematopoietic stem cell transplantation have similar laboratory correlates and clinical outcomes, suggesting that they are individual organ manifestations of a systemic disorder at presentation, a disorder similar to the multiple organ dysfunction syndrome seen in other populations of critically ill patients. Data Sources and Study Selection: Reports of clinical research studies on the natural history and laboratory correlates of central nervous system, pulmonary, and hepatic dysfunction (generally manifesting as the syndrome of hepatic veno-occlusive disease) during hematopoietic stem cell transplantation. Data Extraction and Synthesis: During hematopoietic stem cell transplantation, pulmonary dysfunction (manifesting as hypoxia), central nervous system dysfunction (detected by alteration of the Mini-Mental Status Exam), and hepatic dysfunction (presenting as the syndrome of hepatic veno-occlusive disease) are all associated with significant decreases in the levels of antithrombin III and protein C and an increase in the platelet transfusion requirement. Each of these three organ dysfunctions is associated with a high likelihood of being followed by the other two and, eventually, death. Patients with these organ dysfunctions have higher levels of interleukin-6, interleukin-10, and tumor necrosis factor-« than patients who never develop these complications. Mortality rates for patients with these organ dysfunctions vary from 15% in patients with only one organ dysfunction to 100% in patients who have progressed to all three. Patients who develop none of these organ dysfunctions have a mortality rate that approaches zero. Conclusions: Central nervous system, pulmonary, and hepatic dysfunctions are intimately involved in the mortal complications of hematopoietic stem cell transplantation. Because these organ dysfunctions have similar correlates and similar outcomes, the hypothesis that they are individual parts of a systemic disorder is proposed. The additional observation that these organ dysfunctions are associated with abnormally high levels of inflammation-related cytokines raises the possibility that their pathogenesis is similar to that of multiple organ dysfunction syndrome in other populations of critically ill patients. |
| Databáze: | OpenAIRE |
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