Overdose and death with olanzapine: two case reports
| Autor: | John E. Gerber, Beverly Cawthon |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Drug
Olanzapine Adult Male medicine.medical_specialty media_common.quotation_subject Autopsy Coronary Disease Gastroenterology Pathology and Forensic Medicine Benzodiazepines Fatal Outcome Internal medicine medicine Humans media_common Cause of death Kidney Schizophrenia Paranoid business.industry Medical examiner Pirenzepine Middle Aged medicine.disease medicine.anatomical_structure Schizophrenia Toxicity Drug Overdose business medicine.drug Antipsychotic Agents |
| Zdroj: | The American journal of forensic medicine and pathology. 21(3) |
| ISSN: | 0195-7910 |
| Popis: | Olanzapine is an antipsychotic drug that has been on the market since 1996. Olanzapine-related deaths are very rare; the literature reports only one. However, in a recent 5-month period one medical examiner's office found two such cases that are reported in this paper. One is a suicide and the other is not. The toxicologic and anatomic findings for each are described. Blood olanzapine concentrations ranged from 0.237 microg/ml for one to 0.675 microg/ml for the other. Gastric content concentrations also exhibited a wide range, varying from 0.197 microg/ml to 17.400 microg/ml for the other. Distribution studies of the liver, kidney, and brain produced nondetectable concentrations for the drug. There were no consistent pathologic anatomic findings for cause of death except for moderate coronary atherosclerosis in the nonsuicide case. Both deaths were attributed to olanzapine toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|