| Autor: |
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22455134.v1 |
| Popis: |
PDF file - 954K, Supplemental Figures: Figure S1. Chemical structure of the Akt inhibitor GDC-0068. Figure S2. Effect of GDC-0068 on cell cycle and apoptotic response on PC-3 and MCF7-neo/HER2 cell lines. Figure S3. Western blot analysis of indicated proteins in isogenic MCF10A cells with and without PTEN knockout in the presence of 20 or 0.2 ng/ml EGF. Figure S4. Representative immunohistochemistry staining images of cleaved caspase-3 in TOV-21G.x1 tumors. Figure S5. Combination effects between GDC-0068 and chemotherapeutic agents in vitro. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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