Pituitary adenylate cyclase activating peptide and vasoactive intestinal polypeptide: differentiation effects on human neuroblastoma NB-OK-1 cells
| Autor: | Minoru Hoshino, Min Li, Li-Qin Zheng, Noboru Yanaihara, Mutsuaki Suzuki, T. Mochizuki |
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| Rok vydání: | 1993 |
| Předmět: |
endocrine system
medicine.medical_specialty Neurite Cellular differentiation Vasoactive intestinal peptide Adenylate kinase Biology Cyclase Neuroblastoma Internal medicine Cyclic AMP Neurites Tumor Cells Cultured medicine Humans Chromatography High Pressure Liquid Neurotransmitter Agents Cell growth General Neuroscience Neuropeptides Cell Differentiation Cell biology Pituitary adenylate cyclase-activating peptide Endocrinology Pituitary Adenylate Cyclase-Activating Polypeptide Cell Division hormones hormone substitutes and hormone antagonists Intracellular Vasoactive Intestinal Peptide |
| Zdroj: | Neuroscience Letters. 159:35-38 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(93)90792-j |
| Popis: | Pituitary adenylate cyclase activating peptide-38 (PACAP-38), PACAP-27 and vasoactive intestinal polypeptide (VIP) increased intracellular cAMP content in human neuroblastoma NB-OK-1 cells transiently. PACAP and VIP also arrested cell growth and induced morphological differentiation, which lasted for 24 h in spite of removal of PACAP-38 and PACAP-27. The order of potencies for the neurite outgrowth and the arrest of cell growth is PACAP-38 > PACAP-27 > VIP. The results suggest the possibility that these neuropeptides are new candidates for differentiation activity. |
| Databáze: | OpenAIRE |
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