Do motivation deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of behavioural response to natural rewards and drug cues
Autor: | Clifford M. Cassidy, Ashok Malla, Martin Lepage |
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Rok vydání: | 2013 |
Předmět: |
Drug
Adult Male medicine.medical_specialty Psychosis Marijuana Abuse Visual perception media_common.quotation_subject Population Emotions Marijuana Smoking 03 medical and health sciences 0302 clinical medicine Reward medicine Humans Psychiatry education Biological Psychiatry media_common Cannabis education.field_of_study Motivation biology Cannabinoids Addiction medicine.disease biology.organism_classification 030227 psychiatry Psychiatry and Mental health Schizophrenia Case-Control Studies Female Schizophrenic Psychology Cues Psychology 030217 neurology & neurosurgery Schizophrenia spectrum Clinical psychology |
Zdroj: | Psychiatry research. 215(3) |
ISSN: | 1872-7123 |
Popis: | Deficits in incentive motivation are often present in both Schizophrenia Spectrum Disorders (SSD) and substance-use disorders. The current study aims to test whether the presence of such deficits confers vulnerability to cannabis use in individuals with SSD. SSD patients (n=35) and healthy controls (n=35) were each divided into a group with (n=20) and a group without (n=15) current cannabis use disorder. Subjects performed a behavioural task designed for schizophrenia patients in which they could seek exposure to pleasant and cannabis visual stimuli on the basis of internal representations of these stimuli. Intensity of cannabis use was assessed by self-report. SSD patients were significantly less likely than controls to exert effort to try to re-view pleasant stimuli but were not significantly less likely to work to avoid unpleasant stimuli. Lack of response to re-view pleasant stimuli significantly predicted higher subsequent cannabis self-administration in patients but not controls, after controlling for degree of prior exposure to cannabis. Deficits in incentive motivation may be an aspect of SSD which promotes cannabis use in this population. |
Databáze: | OpenAIRE |
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