Assessment of the DTI‐ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia
| Autor: | Elaine Lui, Roland Bammer, Nicola T. Lautenschlager, David Ames, Charles B Malpas, Vijay K. Venkatraman, Lucy Vivash, Elizabeth V. Cyarto, Dennis Velakoulis, Christopher Steward, Patricia Desmond, Colin L. Masters, Terence J. O'Brien, Kathryn A. Ellis |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty 030218 nuclear medicine & medical imaging 03 medical and health sciences Cognition 0302 clinical medicine Neuroimaging Alzheimer Disease Internal medicine medicine Humans Effective diffusion coefficient Dementia Cognitive Dysfunction Radiology Nuclear Medicine and imaging Perivascular space Aged Aged 80 and over business.industry Brain Middle Aged medicine.disease Diffusion Tensor Imaging medicine.anatomical_structure Susceptibility weighted imaging Cardiology Female Glymphatic system Neurology (clinical) Alzheimer's disease business Glymphatic System 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Neuroimaging. 31:569-578 |
| ISSN: | 1552-6569 1051-2284 |
| DOI: | 10.1111/jon.12837 |
| Popis: | BACKGROUND AND PURPOSE: Recently, there has been growing interest in the glymphatic system (the functional waste clearance pathway for the central nervous system and its role in flushing solutes (such as amyloid s and tau), metabolic, and other cellular waste products in the brain. Herein, we investigate a recent potential biomarker for glymphatic activity (the diffusion tensor imaging along the perivascular space [DTI-ALPS] parameter) using diffusion MRI imaging in an elderly cohort comprising 10 cognitively normal, 10 mild cognitive impairment (MCI), and 16 Alzheimer's disease (AD). METHODS: All 36 participants imaged on a Siemens 3.0T Tim Trio. Single-SE diffusion weighted Echo-planar imaging scans were acquired as well as T1 magnetization prepared rapid gradient echo, T2 axial, and susceptibility weighted imaging. Three millimeter regions of interest were drawn in the projection and association fibers adjacent to the medullary veins at the level of the lateral ventricle. The DTI-ALPS parameter was calculated in these regions and correlated with cognitive status, Mini-Mental State Examination (MMSE), and ADASCog11 measures. RESULTS: Significant correlations were found between DTI-ALPS and MMSE and ADASCog11 in the right hemisphere adjusting for age, sex, and APoE e4 status. Significant differences were also found in the right DTI-ALPS indices between cognitively normal and AD groups (P < .026) and MCI groups (P < .025) in a univariate general linear model corrected for age, sex, and APoE e4. Significant differences in apparent diffusion coefficient between cognitively normal and AD groups were found in the right projection fibers (P = .028). CONCLUSION: Further work is needed to determine the utility of DTI-ALPS index in larger elderly cohorts and whether it measures glymphatic activity. |
| Databáze: | OpenAIRE |
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