Age related decline in aluminum-activated human platelet adenylate cyclase: Post-receptor changes in cyclic AMP second messenger signal amplification in normal aging and dementia of the Alzheimer type
| Autor: | Gerald Oppenheim, Jochanan Stessman, Yehuda van Dijk, Adi Doron, Richard P. Ebstein, Zoli Zlotogorski |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Blood Platelets Male inorganic chemicals Senescence Aging medicine.medical_specialty Adolescent Protein subunit Adenylate kinase Cyclase General Biochemistry Genetics and Molecular Biology Lesion Alzheimer Disease Internal medicine medicine Humans heterocyclic compounds Platelet General Pharmacology Toxicology and Pharmaceutics Receptor Aged Chemistry General Medicine Middle Aged Endocrinology Second messenger system Female medicine.symptom Adenylyl Cyclases Aluminum |
| Zdroj: | Life Sciences. 39:1167-1175 |
| ISSN: | 0024-3205 |
| Popis: | Low, micromolar concentrations of aluminum (in the presence of NaF) were shown to strongly activate human platelet adenylate cyclase and provided a useful probe for evaluating cyclic AMP second messenger function distal to the receptor: The effect of normal aging and disease state on second messenger activity in man was studied by measurements of the aluminum-activated enzyme. A significant decline in aluminum-stimulated platelet adenylate cyclase activity in older, healthy subjects was observed. An age-associated decline in NaF-stimulated cyclic AMP synthesis was also demonstrated for normal, non-demented subjects. These findings suggest an age-associated lesion at the level of the guanine nucleotide regulatory protein/catalytic subunit of the adenylate cyclase complex. However, for patients with Alzheimer's disease no such decline in platelet adenylate cyclase activity was detected, and increased sensitivity to both aluminum and NaF was demonstrated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|