| Autor: |
Chris T. Derk, Wanda Maglione, Ileana Nicoara, Ulrich A. Walker, Alexandra Balbir-Gurman, Evelien Ton, R. E. de Souza, Branimir Anić, Roberto Caporali, L. Lonzetti, Jiri Stork, Daniela Opris, Ina Kötter, Stefan Heitmann, Stefano Bombardieri, J.M. van Laar, Evgeny Nasonov, Paul Hasler, Srdan Novak, S. Alhasani, Yannick Allanore, James R. Seibold, Murat Inanc, C. A. Von Mühlen, Raffaella Scorza, P. Eilbacher, G. Udrea, Oliver Distler, Brigitte Krummel-Lorenz, Britta Maurer, Otylia Kowal-Bielecka, Valeria Riccieri, Gianluca Moroncini, Alberto Sulli, Daniel E. Furst, Susanne Ullman, Y. Braun, Alessandro Mathieu, F. Stoeckl, I. Miniati, Percival D. Sampaio-Barros, Nemanja Damjanov, Henrik Nielsen, Patricia Carreira, Raffaele Pellerito, M. Buslau, Marco Matucci-Cerinic, E. De Langhe, Thierry Zenone, Peter Nash, D. Comina, Armando Gabrielli, Luc Mouthon, Jae Bum Jun, G. Riemekasten, Blaž Rozman, N. Del Papa, L. Alhajjar, Jutta G Richter, Jaap Fransen, Eric Hachulla, Stanislaw Sierakowsky, Miroslav Mayer, Małgorzata Widuchowska, Nicolas Hunzelmann, Ingo H. Tarner, M. Saracco, Coziana Ciurtin, Carlo Chizzolini, Maurizio Cutolo, P. Rehberger, Matthias Seidel, R. Ionitescu, Simona Rednic, Ulf Müller-Ladner, Paola Caramaschi, F.H.J. van den Hoogen, J.A. Pereira da Silva, Camillo Ribi, Christopher P. Denton, S. Bellando Randone, Magdalena Szmyrka-Kaczmarek, A Tyndall, Carmen Pizzorni, D. Launay, Jérôme Avouac, Rene Westhovens, Margitta Worm, Frank A. Wollheim, M. Lemos Lopes, C. Mihai, A. Sipek-Dolnicar, Alessandra Vacca, M. Meurer, Laura Bazzichi, Cord Sunderkötter, Cecília Varjú, Eugeniusz J. Kucharz, Søren Jacobsen, Vanessa Smith, Richard M. Silver, Gabriele Valentini, AT Kotulska, F De Keyser, M. Baresic, E. Rath, Marie Vanthuyne, Carolina de Souza Müller, S. Popa, Guido Valesini, Madelon C. Vonk, Dominique Farge, Ruxandra Ionescu, P. Coelho, B. Granel, A. Della Rossa, Maria João Salvador, T. Tourinho, Annegret Kuhn, Ewa Morgiel, C. Durant, L. Czirják, Maria Uprus, Tatiana Nevskaya, Paolo Amerio, Paolo Airò, Hans P. Kiener, D. Vealex |
| Přispěvatelé: |
Avouac, J, Fransen, J, Walker, Ua, Riccieri, V, Smith, V, Muller, C, Miniati, I, Tarner, Ih, Randone, Sb, Cutolo, M, Allanore, Y, Distler, O, Valentini, Gabriele, Czirjak, L, MÜLLER LADNER, U, Furst, De, Tyndall, A, MATUCCI CERINIC, M, Eustar, Group, University of Zurich |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Annals of the Rheumatic Diseases, 70, 476-81
Annals of the Rheumatic Diseases, 70, 3, pp. 476-81 |
| ISSN: |
1468-2060
0003-4967 |
| Popis: |
ObjectiveTo identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc).MethodsA list of items provided by European League Against Rheumatism (EULAR) Scleroderma Trial and Research(EUSTAR) centres were subjected to a Delphi exercise among 110 experts in the field of SSc. In round 1, experts were asked to choose the items they considered as the most important for the very early diagnosis of SSc. In round 2, experts were asked to reconsider the items accepted after the first stage. In round 3, the clinical relevance of selected items and their importance as measures that would lead to an early referral process were rated using appropriateness scores.ResultsPhysicians from 85 EUSTAR centres participated in the study and provided an initial list of 121 items. After three Delphi rounds, the steering committee, with input from external experts, collapsed the 121 items into three domains containing seven items, developed as follows: skin domain (puffy fingers/puffy swollen digits turning into sclerodactily); vascular domain (Raynaud's phenomenon, abnormal capillaroscopy with scleroderma pattern) and laboratory domain (antinuclear, anticentromere and antitopoisomerase-I antibodies). Finally, the whole assembly of EUSTAR centres ratified with a majority vote the results in a final face-to-face meeting.ConclusionThe three Delphi rounds allowed us to identify the items considered by experts as necessary for the very early diagnosis of SSc. The validation of these items to establish diagnostic criteria is currently ongoing in a prospective observational cohort. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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