Prevalence of amyotrophic lateral sclerosis in Latium region, Italy
| Autor: | Maria, Puopolo, Ilaria, Bacigalupo, Paola, Piscopo, Eleonora, Lacorte, DI PUCCHIO, Alessandra, Marialaura, Santarelli, Inghilleri, Maurizio, Petrucci, Antonio, Mario, Sabatelli, Libonati, Laura, Ceccanti, Marco, Vanacore, Nicola |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty amyotrophic lateral sclerosis Referral Population prevalence Prevalence Neurosciences. Biological psychiatry. Neuropsychiatry epidemiology studies Behavioral Neuroscience Young Adult Medicine Humans Prospective Studies Amyotrophic lateral sclerosis education Retrospective Studies education.field_of_study business.industry Public health public health Original Articles Middle Aged medicine.disease Italy Sample size determination neurodegenerative Prevalence studies Female Original Article business RC321-571 Demography |
| Zdroj: | Brain and Behavior Brain and Behavior, Vol 11, Iss 12, Pp n/a-n/a (2021) |
| ISSN: | 2162-3279 |
| Popis: | Objective Prevalence estimate of amyotrophic lateral sclerosis (ALS) ranged between 1.1/100,000 and 11.2/100,000 inhabitants with different design of the study (prospective or retrospective) and sample size. The aim of this study is to conduct for the first time an estimate of the ALS prevalence in the Latium region. Materials and methods The study was performed in Latium, a region located in the center of Italy, with a population, as of January 1, 2016, of 5888.472 inhabitants. In this region, a network of 15 clinical centers (of which 4 referral ALS centers are located in Rome) and 10 local health authorities involved in the diagnosis and treatment of ALS patients has been identified. Each patient was classified according to the El Escorial revised criteria. Results The prevalence study in 2016 identified 353 ALS cases (200 males). By considering population aged >=20 years, the total crude prevalence rate resulted 7.33 (CI95% 6.59–8.14) × 100,000 and 8.75 and 6.05 in males and females, respectively. Age‐specific prevalence rates did not differ among males and females in the population aged less than 49 years. The difference emerged in population aged > 50 years. This type of diagnosis was recorded for 343 patients (11 missing). 68% of these patients have a definite diagnosis, 14% likely, 11% possible, and 12% defined as suspect. Conclusions The estimate of prevalence rates observed in this study is probably in line with the values reported in the literature for prospective prevalence studies. The aim of this study is to conduct for the first time, an estimate of the amyotrophic lateral sclerosis prevalence in the Latium region. |
| Databáze: | OpenAIRE |
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