Inflammation-Related Pancreatic Carcinogenesis
| Autor: | Xing-Peng Wang, Ling Tian, Juan-juan Dai, Ming-jie Jiang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Inflammation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Endocrinology Internal Medicine medicine Animals Humans Enhancer Pancreas Transcription factor chemistry.chemical_classification Reactive oxygen species Aspirin Hepatology business.industry Anti-Inflammatory Agents Non-Steroidal NF-kappa B Cell Transformation Neoplastic 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Pancreatic carcinogenesis medicine.symptom Reactive Oxygen Species Carcinogenesis business |
| Zdroj: | Pancreas. 46:973-985 |
| ISSN: | 1536-4828 0885-3177 |
| DOI: | 10.1097/mpa.0000000000000886 |
| Popis: | Chronic inflammation has long been considered critical in pancreatic carcinogenesis, and recently studies showed that some anti-inflammatory agents such as aspirin could potentially be used to attenuate pancreatic carcinogenesis. Several inflammation-related critical transcription factors and pathways such as NF-κB (nuclear factor κ-light-chain enhancer of activated B cells) and reactive oxygen species have been confirmed to be involved in carcinogenesis. However, its underlying mechanisms are far from clear, which largely limits further development of potential anticarcinogenesis drugs. As a result, it is of great importance for us to better understand and gain a better perspective in inflammation-related pancreatic carcinogenesis. In this review, we systematically analyzed recent advances concerning inflammation-related pancreatic carcinogenesis and brought out the possible underlying mechanisms. Potential preventive and therapeutic strategies based on anti-inflammatory agents have also been further discussed. |
| Databáze: | OpenAIRE |
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