Structural abnormalities in nucleus accumbens in patients with panic disorder
Autor: | Haruhisa Yoshida, Thomas J. Whitford, Yoshio Hirayasu, Takeshi Asami, Asuka Yoshimi, Ryota Nakamura, Masao Takaishi |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Audiology Nucleus accumbens Anxiety Nucleus Accumbens 03 medical and health sciences 0302 clinical medicine mental disorders medicine Trait anxiety Animals Humans In patient business.industry Panic disorder Panic Fear medicine.disease Anxiety Disorders 030227 psychiatry Psychiatry and Mental health Clinical Psychology Psychotropic drug nervous system Panic Disorder Animal studies medicine.symptom business psychological phenomena and processes 030217 neurology & neurosurgery |
Zdroj: | Journal of affective disorders. 271 |
ISSN: | 1573-2517 |
Popis: | Background : Although the pathogenesis of panic attacks has been well studied in patients with panic disorder (PD), the neurobiological basis of the long-term fear memories and avoidance behavior that are often observed in PD have not been well investigated. Recent animal studies have suggested that nucleus accumbens (NAcc) plays an important role in neurobiological basis of long-term fear memories and avoidance behavior. Methods : Thirty-eight patients with PD and 38 matched healthy control subjects (HC) participated in this study. Differences in relative volumes and shape deformations of NAcc were evaluated between groups. Correlation analyses were conducted to quantify the association between structural abnormalities in the NAcc and trait, state anxiety measured by the State-Trait Anxiety Inventory (STAI). Results : Significant volume reductions were observed in the bilateral NAcc in the patients with PD, relative to the HC. In terms of shape differences, the PD patients demonstrated significant inward deformation of the NAcc bilaterally, compared to the HC. Degree of shape deformation in the right NAcc was associated with higher scores of the STAI-Trait, and STAI-State measures in the PD patients. Limitations : All the patients received medication such as Psychotropic drug. Conclusion : Patients with PD showed reduced volumes in the NAcc, especially in lateral regions, compared with HC. Furthermore, shape deformation in the right NAcc was associated with trait anxiety and state anxiety, which has been associated with avoidance behavior. |
Databáze: | OpenAIRE |
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