Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion
| Autor: | Christopher J. Ong, Ronald P.C. Wong, Magdalena Martinka, Gholamreza Safaee Ardekani, Shahram Khosravi, Gang Li, Guohong Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Skin Neoplasms Apoptosis Cell Growth Processes Biology Phosphatidylinositol 3-Kinases 03 medical and health sciences patient survival 0302 clinical medicine Peptide Initiation Factors Cell Line Tumor EIF5A2 Biomarkers Tumor melanoma medicine Humans Neoplasm Invasiveness Molecular Diagnostics Protein kinase B PI3K/AKT/mTOR pathway 030304 developmental biology 0303 health sciences Tissue microarray Cell growth Akt Melanoma RNA-Binding Proteins Cancer Prognosis invasion medicine.disease 3. Good health Oncology 030220 oncology & carcinogenesis Cutaneous melanoma Disease Progression Cancer research Matrix Metalloproteinase 2 Skin cancer Proto-Oncogene Proteins c-akt prognostic marker |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2013.688 |
| Popis: | Background: Cutaneous melanoma is a life-threatening skin cancer because of its poorly understood invasive nature and high metastatic potential. This study examines the importance of eukaryotic translation initiation factor 5A2 (EIF5A2) in melanoma pathogenesis. Methods: We examined EIF5A2 expression in 459 melanocytic lesions using tissue microarray. In addition, melanoma cell lines were subjected to invasion and cell proliferation assays, zymography, FACS and real-time PCR to investigate the role of EIF5A2 in cancer progression. Results: Positive EIF5A2 staining increased from dysplastic naevi to primary melanomas (PMs; P=0.001), and further increased in metastatic melanomas (P=0.044). Eukaryotic translation initiation factor 5A2 expression was correlated with melanoma thickness (P |
| Databáze: | OpenAIRE |
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