RETRACTED: miR-199a-5p suppresses epithelial- mesenchymal-transition in anaplastic thyroid carcinoma cells via targeting Snail signals
| Autor: | Shukai Sun, Ya-Nan Bi, Yubing Wang, Yichuan Huang, Fengyun Hao, Lei Wang, Jilei Ma, Dong Chen, Xuelong Jiao, Liang Ning, Xuhua Li, Ping Cui |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Epithelial-Mesenchymal Transition Lung Neoplasms Biopsy Fine-Needle Thyroid Gland Down-Regulation Snail Thyroid Carcinoma Anaplastic law.invention Metastasis Mice 03 medical and health sciences 0302 clinical medicine Cell Movement In vivo law Cell Line Tumor biology.animal microRNA Genetics medicine Animals Humans Neoplasm Invasiveness Thyroid Neoplasms Epithelial–mesenchymal transition Cell Proliferation 030304 developmental biology 0303 health sciences biology Cancer General Medicine medicine.disease Xenograft Model Antitumor Assays In vitro Gene Expression Regulation Neoplastic MicroRNAs Oncology 030220 oncology & carcinogenesis Disease Progression Thyroidectomy Cancer research Suppressor Snail Family Transcription Factors |
| Zdroj: | Cancer Biomarkers. 29:317-326 |
| ISSN: | 1875-8592 1574-0153 |
| DOI: | 10.3233/cbm-201518 |
| Popis: | MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of anaplastic thyroid carcinoma (ATC). miR-199a-5p was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in ATC remain unclear. Here, we find that miR-199a-5p is significantly downregulated in ATC tissues compared with adjacent non-cancerous tissues. Overexpression of miR-199a-5p significantly inhibits migration and invasion of ATC cells in vitro, and lung metastasis in vivo. Importantly, miR-199a-5p suppresses epithelial-mesenchymal transition (EMT) both in vitro and in vivo by targeting Snail. Taken together, this study reveals that miR-199a-5p is critical to the EMT progression in ATC cells. Targeting the pathway described here may be a novel approach for inhibiting metastasis of ATC. |
| Databáze: | OpenAIRE |
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