Standing up to the cardiometabolic consequences of hematological cancers
| Autor: | David W. Dunstan, Julie R. McMullen, Erin J. Howden, Neville Owen, Andre La Gerche, Sharon Avery, Bronwyn A. Kingwell, Garry L. Jennings, Jane F Arthur |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Heart Diseases Context (language use) Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Metabolic Diseases Deconditioning Internal medicine Diabetes mellitus medicine Animals Humans Obesity Cardiotoxicity Leukemia Physical activity business.industry Diabetes Hematological cancer Cardiac function Disease Management Cancer Hematology Cardiovascular disease medicine.disease Combined Modality Therapy Sedentary behavior Hematologic Neoplasms 030220 oncology & carcinogenesis Heart Function Tests Physical deconditioning Metabolic syndrome Energy Metabolism business |
| Zdroj: | Blood Reviews. 32:349-360 |
| ISSN: | 0268-960X |
| Popis: | Hematological cancer survivors are highly vulnerable to cardiometabolic complications impacting long-term health status, quality of life and survival. Elevated risk of diabetes and cardiovascular disease arises not only from the effects of the cancers themselves, but also from the toxic effects of cancer therapies, and deconditioning arising from reduced physical activity levels. Regular physical activity can circumvent or reverse adverse effects on the heart, skeletal muscle, vasculature and blood cells, through a combination of systemic and molecular mechanisms. We review the link between hematological cancers and cardiometabolic risk with a focus on adult survivors, including the contributing mechanisms and discuss the potential for physical activity interventions, which may act to oppose the negative effects of both physical deconditioning and therapies (conventional and targeted) on metabolic and growth signaling (kinase) pathways in the heart and beyond. In this context, we focus particularly on strategies targeting reducing and breaking up sedentary time and provide recommendations for future research. |
| Databáze: | OpenAIRE |
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