A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions
| Autor: | Sarah M. Merrill, Jared A. Nielsen, Franco Fabbro, Michael D. Fox, Frédéric L.W.V.J. Schaper, Michael A. J. Ferguson, Shan H. Siddiqi, Jordan Grafman, Alexander L. Cohen, Cosimo Urgesi |
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| Přispěvatelé: | Neurochirurgie, RS: MHeNs - R3 - Neuroscience |
| Rok vydání: | 2022 |
| Předmět: |
SYMPTOMS
DESIRE Pain Periaqueductal gray LOVE Imaging Religiosity Lesion Spirituality medicine Humans Fear conditioning Hyper-religiosity Lesion network mapping Religion Biological Psychiatry TEMPERAMENT Brain Human brain medicine.anatomical_structure TRANSCENDENCE Brain lesions Brainstem Nervous System Diseases NETWORK LOCALIZATION medicine.symptom Psychology Neuroscience |
| Zdroj: | Biological Psychiatry, 91(4), 380-388. Elsevier Science Web of Science |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2021.06.016 |
| Popis: | BACKGROUND: Over 80% of the global population consider themselves religious, with even more identifying as spiritual, but the neural substrates of spirituality and religiosity remain unresolved.METHODS: In two independent brain lesion datasets (N1 = 88; N2 = 105), we applied lesion network mapping to test whether lesion locations associated with spiritual and religious belief map to a specific human brain circuit.RESULTS: We found that brain lesions associated with self-reported spirituality map to a brain circuit centered on the periaqueductal gray. Intersection of lesion locations with this same circuit aligned with self-reported religiosity in an independent dataset and previous reports of lesions associated with hyper-religiosity. Lesion locations causing delusions and alien limb syndrome also intersected this circuit.CONCLUSIONS: These findings suggest that spirituality and religiosity map to a common brain circuit centered on the periaqueductal gray, a brainstem region previously implicated in fear conditioning, pain modulation, and altruistic behavior. |
| Databáze: | OpenAIRE |
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