Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells
| Autor: | Yi‑Xing Duan, Qiang Zhou, Yuan Wei Li, Qiang Lu, Sheng Hu, Wan Rui Wu, Zhi‑Yong Gao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research Cell growth Cell Articles Cell cycle Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology Apoptosis 030220 oncology & carcinogenesis Cancer cell medicine Cancer research biology.protein Tensin PTEN Protein kinase B |
| Zdroj: | Oncology letters. 12(4) |
| ISSN: | 1792-1074 |
| Popis: | Deoxypodophyllotoxin (DPPT) is extracted and separated from citrus-related plants, including Podophyllum (P.) peltatum, P. pleianthum, P. emodi (also called P. hexandrum) and Diphylleia grayi. DPPT has significant antitumor and antiviral activity. However, due to its strong toxicity and side effects, its use is limited in practical applications. The in vitro antitumor efficacy of DPPT on human prostate cancer (PCa) cells remains to be determined. The present study investigated the anticancer effect of DPPT on human PCa cells and its potential mechanism. The data revealed that DPPT markedly reduced cell proliferation and activated the caspase-3 expression level by an increase in apoptotic cell death in DU-145 cells. In addition, treatment with DPPT markedly downregulated the levels of phosphorylated Akt and activated the p53/B-cell lymphoma 2 associated X protein (Bax)/phosphatase and tensin homolog (PTEN) signaling pathway in DU-145 cells, suggesting that caspase-mediated pathways were involved in DPPT-induced apoptosis. The present study suggested the role of DPPT as a novel chemotherapeutic drug for human PCa, which may function through the Akt/p53/Bax/PTEN signaling pathway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|