Nanoparticulate bioactive-glass-reinforced gellan-gum hydrogels for bone-tissue engineering
| Autor: | Vitor M. Correlo, Lucília P. da Silva, Saša Novak, Joaquim M. Oliveira, Ana Gantar, Rui L. Reis, Alexandra P. Marques |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Scaffold
Materials science Simulated body fluid Composite number Bioengineering Composite 02 engineering and technology 010402 general chemistry 01 natural sciences Apatite Bone and Bones law.invention Biomaterials chemistry.chemical_compound law Bioactive glass Composite material Science & Technology Tissue Engineering Polysaccharides Bacterial Hydrogels 021001 nanoscience & nanotechnology Microstructure Gellan gum Gellan Gum 3. Good health 0104 chemical sciences chemistry Bone-tissue engineering Mechanics of Materials visual_art Self-healing hydrogels visual_art.visual_art_medium Microscopy Electron Scanning Nanoparticles Glass 0210 nano-technology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | his work presents bioactive-glass-reinforced gellan-gum spongy-like hydrogels (GG-BAG) as novel hydrophilic materials for use as the scaffolding in bone-tissue engineering. The reinforcement with bioactive-glass particles resulted in an improvement to the microstructure and to the mechanical properties of the material. These mechanical properties were found to be dependent on the composition and improved with the amount of bioactive glass; however, values necessary to accommodate biomechanical loading were not achieved in this study. Nevertheless, by incorporating the bioactive-glass particles, the composite material acquired the ability to form an apatite layer when soaked in simulated body fluid. Furthermore, human-adipose-derived stem cells were able to adhere and spread within the gellan-gum, spongy-like hydrogels reinforced with the bioactive glass, and remain viable, which is an important result when considering their use in bone-tissue engineering. Thus, hydrogels based on gellan gum and bioactive glass are promising biomaterials for use either alone or with cells, and with the potential for use in osteogenic differentiation. The Slovenian Research Agency is acknowledged for its financial support of the PhD study of the first author, Ms. Ana Gantar. This work was partly performed within the short-term scientific mission (STSM reference number: ECOST-STSM-MP1005-250912-020779) of Ms. Gantar in the 3B's group under the COST Action MP1005 "From nano to macro biomaterials (design, processing, characterization, modelling) and applications to stem cell regenerative orthopaedic and dental medicine - NAMABIO". The authors wish to thank Dr Paul McGuiness for proofreading the article. |
| Databáze: | OpenAIRE |
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