Manual microdissection technique in a case of subcutaneous panniculitis-like T-cell lymphoma: a case report and review
| Autor: | Shane Meehan, Marsha Chaffins, Milena Cankovic, Koichi Maeda, Daniel M. Hoffman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Panniculitis Skin Neoplasms Histology Population Dermatology Biology Pathology and Forensic Medicine Subcutaneous Tissue Subcutaneous Panniculitis-Like T-Cell Lymphoma medicine Humans Gene Rearrangement beta-Chain T-Cell Antigen Receptor Pathology Molecular education Microdissection education.field_of_study Gene Rearrangement gamma-Chain T-Cell Antigen Receptor Molecular pathology Cutaneous T-cell lymphoma Clinical course DNA Neoplasm Middle Aged medicine.disease Clone Cells Lymphoma T-Cell Cutaneous Lymphoma Reactive lymphocyte Female |
| Zdroj: | Journal of Cutaneous Pathology. 39:769-772 |
| ISSN: | 0303-6987 |
| Popis: | Demonstration of T-cell receptor gene monoclonality often plays an important role in the diagnosis of T-cell lymphoma. When a test to detect monoclonality is performed on whole tissue sections, the presence of a reactive lymphocyte population may reduce sensitivity. This may be especially true for early or borderline cases of lymphoma. Microdissection techniques may be utilized to more readily identify a clonal population of lymphocytes. Subcutaneous panniculitis-like T-cell lymphoma represents a cutaneous lymphoid neoplasm whose clinical course may vary from an indolent, waxing and waning course to an aggressive course resulting in death. We report the first case of a microdissection technique used to facilitate diagnosing a case of subcutaneous panniculitis-like T-cell lympoma. Hoffman D, Chaffins M, Cankovic M, Maeda K, Meehan S. Manual microdissection technique in a case of subcutaneous panniculitis-like T-cell lymphoma: a case report and review. |
| Databáze: | OpenAIRE |
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