Changes in the severity of aortic regurgitation at peak effort during exercise
| Autor: | Pere Pericas, Andrés Carrillo López, José Francisco Forteza Albertí, Antonio Rodríguez Fernández, Francisco Javier Calderón Montero, Marta Noris Mora, Lucía Pasamar Márquez |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Rest Aortic Valve Insufficiency Diastole Cardiac index Regurgitation (circulation) 030204 cardiovascular system & hematology Asymptomatic Severity of Illness Index Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Sinus rhythm 030212 general & internal medicine Exercise Ejection fraction business.industry Stroke Volume Middle Aged Blood pressure medicine.anatomical_structure Ventricle Echocardiography cardiovascular system Cardiology Exercise Test Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | International journal of cardiology. 228 |
| ISSN: | 1874-1754 |
| Popis: | Background Chronic aortic regurgitation can be well tolerated for a long time. Some patients with normal ventricular function can even reach high levels of sporting performance. How the severity of regurgitation may change during exercise, however, is little known, although some studies suggest it diminishes. The present work examines, during exercise, the functional capacity, ventricular function, and regurgitation fraction (RF) in asymptomatic subjects with moderate or severe aortic regurgitation with preserved ejection fraction. Methods The study subjects ( n =32; 23 men, 9 women) were patients referred to our echocardiography laboratory with moderate or severe aortic regurgitation, preserved left ventricular systolic function, and sinus rhythm into NYHA functional class I. All underwent transthoracic echocardiography at rest and at peak effort during an exercise protocol involving an inclined cycloergometer. Left atrial and ventricular volume indices were recorded, along with diastolic and systolic function, cardiac index, peripheral resistance, and RF. Results The mean age of the subjects was 43.8±18.2years; 59% suffered moderate regurgitation, 41% severe aortic regurgitation, and 84% had a dilated left ventricle. All subjects managed exercise loads adequate for their age. Peak effort was associated with a significant reduction (mean 44.5% [range 10–95%]) in the RF (21.8±13.2 vs. 39.3%±14.7% at rest; p =0.0001). The absolute reduction in the RF at peak effort was greater among the subjects with severe aortic regurgitation (21.2% vs. 13.3% in those with moderate regurgitation; p =0.018). Conclusions The RF becomes smaller during exercise in asymptomatic subjects with moderate or severe aortic regurgitation and preserved ventricular function. |
| Databáze: | OpenAIRE |
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