An overview on the recently discovered iota-carbonic anhydrases

Autor:	Alessio Nocentini, Clemente Capasso, Claudiu T. Supuran
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Burkholderia Bicarbonate Thalassiosira pseudonana Review Review Article RM1-950 Cyanobacteria medicine.disease_cause Cofactor law.invention chemistry.chemical_compound law Drug Discovery medicine Gene family bacteria catalytic pocket Burkholderia territorii Pharmacology chemistry.chemical_classification carbonic anhydrases biology Eukaryota General Medicine biology.organism_classification humanities Enzyme chemistry Biochemistry Bigelowiella natans Biocatalysis Recombinant DNA biology.protein hydratase activity ca classes Therapeutics. Pharmacology
Zdroj:	Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1988-1995 (2021) Journal of enzyme inhibition and medicinal chemistry 36 (2021): 1988–1995. doi:10.1080/14756366.2021.1972995 info:cnr-pdr/source/autori:Nocentini A.; Supuran C.T.; Capasso C./titolo:An overview on the recently discovered iota-carbonic anhydrases/doi:10.1080%2F14756366.2021.1972995/rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2021/pagina_da:1988/pagina_a:1995/intervallo_pagine:1988–1995/volume:36 Journal of Enzyme Inhibition and Medicinal Chemistry article-version (VoR) Version of Record
ISSN:	1475-6374 1475-6366
DOI:	10.1080/14756366.2021.1972995
Popis:	Carbonic anhydrases (CAs, EC 4.2.1.1) have been studied for decades and have been classified as a superfamily of enzymes which includes, up to date, eight gene families or classes indicated with the Greek letters α, β, γ, δ, ζ, η, θ, ι. This versatile enzyme superfamily is involved in multiple physiological processes, catalysing a fundamental reaction for all living organisms, the reversible hydration of carbon dioxide to bicarbonate and a proton. Recently, the ι-CA (LCIP63) from the diatom Thalassiosira pseudonana and a bacterial ι-CA (BteCAι) identified in the genome of Burkholderia territorii were characterised. The recombinant BteCAι was observed to act as an excellent catalyst for the physiologic reaction. Very recently, the discovery of a novel ι-CAs (COG4337) in the eukaryotic microalga Bigelowiella natans and the cyanobacterium Anabaena sp. PCC7120 has brought to light an unexpected feature for this ancient superfamily: this ι-CAs was catalytically active without a metal ion cofactor, unlike the previous reported ι-CAs as well as all known CAs investigated so far. This review reports recent investigations on ι-CAs obtained in these last three years, highlighting their peculiar features, and hypothesising that possibly this new CA family shows catalytic activity without the need of metal ions.
Databáze:	OpenAIRE
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