The Rise of Glutaminase in End-Stage Liver Diseases
| Autor: | M Jover-Cobos, Nathan Davies, Rajiv Jalan, Manuel Romero-Gómez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Cirrhosis business.industry Glutaminase Hyperammonemia medicine.disease Chronic liver disease Gastroenterology 3. Good health Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030211 gastroenterology & hepatology Liver dysfunction Stage (cooking) business Hepatic encephalopathy 030304 developmental biology |
| Zdroj: | Liver Transplantation-Basic Issues |
| Popis: | Ammonia plays a major role in the pathogenesis of hepatic encephalopathy (HE). Systemic hyperammonemia has been largely found in patients with HE with underlying cirrhosis and acute liver failure. HE is associated with a poor prognosis of both acute and chronic liver disease (Bustamante, Rimola et al. 1999; Hui, Chan et al. 2002). Cirrhosis is the major cause of chronic liver dysfunction and affects 6.5 million people worldwide (Eurostat. 2010, as cited in Albrecht, 2010). HE is the hallmark for acute liver failure (ALF), a syndrome with very high mortality in which liver transplant is the often the only effective treatment. |
| Databáze: | OpenAIRE |
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