Contemporary therapeutic management of locally advanced hypopharyngeal cancer: oncologic and functional outcomes – a report on 100 cases

Autor:	Juliette Haudebourg, Alexandre Bozec, Emmanuel Chamorey, Jean-Michel Hannoun-Levi, Clair Vandersteen, Karen Benezery, Anne Sudaka, François Demard, J.-C. Riss, Frederic Peyrade, Marie-Eve Chand, Axel Leyssale, C S Pierre, Marc Ettaiche, Gilles Poissonnet, José Santini, Olivier Dassonville
Rok vydání:	2015
Předmět:	Adult Male Oncology medicine.medical_specialty medicine.medical_treatment Locally advanced Laryngectomy Pharyngectomy Internal medicine medicine Overall survival Humans Stage (cooking) Aged Retrospective Studies Aged 80 and over Hypopharyngeal Neoplasms business.industry Induction chemotherapy Retrospective cohort study Hypopharyngeal cancer General Medicine Middle Aged Total pharyngolaryngectomy medicine.disease Radiation therapy Otorhinolaryngology Carcinoma Squamous Cell Female France business
Zdroj:	Acta Oto-Laryngologica. 135:193-200
ISSN:	1651-2251 0001-6489
Popis:	A significant proportion of patients with locally advanced hypopharyngeal cancer could not be managed by larynx-sparing therapy. T4 stage is one of the main predictive factors of oncologic and functional outcomes.To analyze the therapeutic management of patients with locally advanced hypopharyngeal cancer in clinical practice and to report oncologic and functional outcomes.This was a retrospective study of all patients treated for a locally advanced hypopharyngeal squamous cell carcinoma between 2001 and 2012 at our institution.A total of 100 patients were included in this study. Induction chemotherapy (CT) followed by radiotherapy (RT) ± CT, primary RT + CT, and primary total pharyngolaryngectomy (TPL) comprised the initial therapeutic management for 54, 24, and 20 patients, respectively. Two patients received only supportive care. Overall survival (OS) and cause-specific survival (SS) were 50% and 60% at 3 years, respectively. In the group of patients referred for induction CT, the 3-year OS and SS were 58% and 70%, respectively. In multivariate analysis, T stage (p = 0.05) and ASA score (p = 0.02) were significant predictive factors of OS. T4 tumor stage had a pejorative impact on swallowing function after therapy (p = 0.006). The rate of patients alive, disease-free, and with a functional larynx at 2 years was 23%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09018275f81e71eed0546645c8260f3b https://doi.org/10.3109/00016489.2014.968673 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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