Pulmonary hypertension in lambs with congenital diaphragmatic hernia: Vasodilator prostaglandins, isoprenaline, and tolazoline
| Autor: | Christopher M. Lee, W.D. Andrew Ford, Sudipta Sen, Andrew Barker |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Hypertension Pulmonary Blood Pressure Pulmonary Artery Internal medicine medicine.artery Isoprenaline medicine Animals Humans Diaphragmatic hernia Tolazoline Hernia Diaphragmatic Sheep Prostaglandin D2 business.industry Isoproterenol Congenital diaphragmatic hernia General Medicine Hypoxia (medical) medicine.disease Pulmonary hypertension Disease Models Animal medicine.anatomical_structure Anesthesia Pediatrics Perinatology and Child Health Pulmonary artery Cardiology Surgery medicine.symptom Hernias Diaphragmatic Congenital business Blood Flow Velocity medicine.drug Artery |
| Zdroj: | Journal of Pediatric Surgery. 25:487-491 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/0022-3468(90)90556-o |
| Popis: | After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension. When rendered hypoxic, these, and normal lambs, showed an increase in pulmonary artery pressure, a decrease in systemic pressure, and a decrease in pulmonary blood flow. All of the drugs altered that response, but to different degrees. None of the drugs tested was consistently successful in reversing the adverse affects of hypoxia, but prostaglandin D2 came closest to the ideal vasodilator, decreasing the pulmonary artery pressure in all seven hypoxic lambs having a diaphragmatic hernia. There was a concomitant increase in pulmonary blood flow in six; in the remaining lamb the decrease in blood flow induced by the hypoxia was arrested. At the same time, there was an increase in systemic artery pressure in three, the decrease was arrested in two, but the decrease continued in the other two. Isoprenaline was a more effective drug than tolazoline, producing an increase in pulmonary blood flow in five of the seven lambs, with minor decreases in systemic pressure in five. Tolazo-line improved blood flow in three of six lambs (not all lambs survived the full study), with a marked decrease in systemic pressure in four of them. Prostaglandin D2 seems to be a useful drug for the treatment of patients having diaphragmatic hernias and pulmonary hypertension, and warrants further study. Isoprenaline was the most effective of the readily available drugs tested in this animal model. |
| Databáze: | OpenAIRE |
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