Follow-Up Study of Adolescents Exposed to Di(2-Ethylhexyl) Phthalate (DEHP) as Neonates on Extracorporeal Membrane Oxygenation (ECMO) Support

Autor: Susan B. Nunez, Naomi L.C. Luban, Mary Revenis, Khodayar Rais-Bahrami, Billie L. Short
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Male
medicine.medical_specialty
endocrine system
Adolescent
Health
Toxicology and Mutagenesis
medicine.medical_treatment
010501 environmental sciences
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Animal data
Child Development
Extracorporeal Membrane Oxygenation
Internal medicine
Diethylhexyl Phthalate
Extracorporeal membrane oxygenation
Medicine
Humans
Durable Medical Equipment
Gonads
Testosterone
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
DEHP
business.industry
Thyroid
Puberty
Public Health
Environmental and Occupational Health
Phthalate
Infant
Newborn
toxicity
Articles
3. Good health
medicine.anatomical_structure
Endocrinology
chemistry
Toxicity
Children's Health
Female
ECMO
business
Luteinizing hormone
Hormone
Follow-Up Studies
Zdroj: Environmental Health Perspectives
ISSN: 1552-9924
0091-6765
Popis: Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are blood exchange transfusions, extracorporeal membrane oxygenation (ECMO), and cardiovascular surgery. Although potential exposure to DEHP in ECMO patients is significant, the exposure has not been associated with short-term toxicity. To evaluate long-term toxicity, we undertook a study of neonatal ECMO survivors to assess their onset of puberty and sexual maturity. We evaluated 13 male and 6 female subjects at 14-16 years of age who had undergone ECMO as neonates. All subjects had a complete physical examination including measurements for height, weight, head circumference, and pubertal assessment by Tanner staging. The testicular volume and the phallic length were measured in male participants. Laboratory tests included thyroid, liver, and renal function as well as measurements of luteinizing hormone, follicle-stimulating hormone, testosterone for males, and estradiol for females. Except for one patient with Marfan syndrome, the rest had normal growth percentile for age and sex. All had normal values for thyroid, liver, and renal functions. Sexual hormones were appropriate for the stage of pubertal maturity. Our results indicate that adolescents exposed to significant quantities of DEHP as neonates showed no significant adverse effects on their physical growth and pubertal maturity. Thyroid, liver, renal, and male and female gonadal functions tested were within normal range for age and sex distribution. Key Words: DEHP, ECMO, toxicity.
Databáze: OpenAIRE
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