Cancer Risk Among Tetrafluoroethylene Synthesis and Polymerization Workers
| Autor: | John W. Cherrie, Ilaria Colombo, Anne Sleeuwenhoek, J. Morel Symons, Paolo Bonetti, Kurt Straif, Pier Alberto Bertazzi, Ludovic G. P. M. van Amelsvoort, David G. Farrar, John A. Tomenson, Dario Consonni |
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| Přispěvatelé: | Epidemiologie, RS: CAPHRI School for Public Health and Primary Care |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology Epidemiology neoplasms Cumulative Exposure Gastroenterology Risk Assessment Polymerization cohort studies Internal medicine Cause of Death Occupational Exposure medicine Humans Cause of death polytetrafluoroethylene Fluorocarbons Leukemia business.industry Incidence (epidemiology) Liver Diseases Liver Neoplasms Cancer medicine.disease mortality Confidence interval Kidney Neoplasms United States Europe Occupational Diseases Survival Rate Standardized mortality ratio Chemical Industry Cohort occupational health Female Kidney Diseases tetrafluoroethylene Liver cancer business Environmental Monitoring |
| Zdroj: | American Journal of Epidemiology, 178(3), 350-358. Oxford University Press |
| ISSN: | 0002-9262 |
| DOI: | 10.1093/aje/kws588 |
| Popis: | Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene, increases the incidence of liver and kidney cancers and leukemia in rats and mice. This is the first time the cancer risk in humans has been explored comprehensively in a cohort mortality study (1950-2008) that included all polytetrafluoroethylene production sites in Europe and North America at the time it was initiated. A job-exposure matrix (1950-2002) was developed for TFE and ammonium perfluoro-octanoate, a chemical used in the polymerization process. National reference rates were used to calculate standardized mortality ratios (SMRs) and 95% confidence intervals. Among 4,773 workers ever exposed to TFE, we found a lower rate of death from most causes, as well as increased risks for cancer of the liver (SMR = 1.27; 95% confidence interval: 0.55, 2.51; 8 deaths) and kidney (SMR = 1.44; 95% confidence interval: 0.69, 2.65; 10 deaths) and for leukemia (SMR = 1.48; 95% confidence interval: 0.77, 2.59; 12 deaths). A nonsignificant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and ammonium perfluoro-octanoate exposures were highly correlated, and therefore their separate effects could not be disentangled. This pattern of findings narrows the range of uncertainty on potential TFE carcinogenicity but cannot conclusively confirm or refute the hypothesis that TFE is carcinogenic to humans. |
| Databáze: | OpenAIRE |
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