Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis
| Autor: | Hamed Horati, Bob J. Scholte, Camilla Margaroli, M. Veltman, Jeffrey Chou, Matthew B. Kilgore, Marta Stolarczyk, Hettie M. Janssens, Harm A.M.W. Tiddens, Joshua D. Chandler, Limin Peng, Rabindra Tirouvanziam |
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| Přispěvatelé: | Pediatrics, Cell biology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Cystic Fibrosis Respiratory System medicine.disease_cause Cystic fibrosis Article Bronchoscopy medicine Humans Longitudinal Studies Inflammation Bronchiectasis Lung biology medicine.diagnostic_test business.industry Infant respiratory system Lipid Metabolism medicine.disease Cystic fibrosis transmembrane conductance regulator respiratory tract diseases Oxidative Stress Bronchoalveolar lavage medicine.anatomical_structure Child Preschool Neutrophil elastase Myeloperoxidase Pediatrics Perinatology and Child Health Disease Progression biology.protein Cytokines Intercellular Signaling Peptides and Proteins Female Tomography X-Ray Computed business Bronchoalveolar Lavage Fluid Biomarkers Oxidative stress |
| Zdroj: | Journal of Cystic Fibrosis, 19(6), 902-909. Elsevier J Cyst Fibros |
| ISSN: | 1873-5010 1569-1993 |
| Popis: | BACKGROUND: Previously, we showed that abnormal levels of bioactive lipids in bronchoalveolar lavage fluid (BALF) from infants with cystic fibrosis (CF) correlated with early structural lung damage. METHOD: To extend these studies, BALF bioactive lipid measurement by mass spectrometry and chest computed tomography (CT, combined with the sensitive PRAGMA-CF scoring method) were performed longitudinally at 2-year intervals in a new cohort of CF children (n=21, aged 1–5 yrs). RESULTS: PRAGMA-CF, neutrophil elastase activity, and myeloperoxidase correlated with BALF lysolipids and isoprostanes, markers of oxidative stress, as well as prostaglandin E2 and combined ceramide precursors (Spearman’s Rho >0.5; P |
| Databáze: | OpenAIRE |
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