The Upsides and Downsides of Organelle Interconnectivity
| Autor: | Thomas Nyström, Daniel E. Gottschling |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging media_common.quotation_subject Feedback control Context (language use) Saccharomyces cerevisiae Biology Interconnectivity General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Organelle Animals Humans Function (engineering) Complex adaptive system media_common Cognitive science Organelles Proteins Budding yeast Cell biology 030104 developmental biology Proteostasis Cell Division Signal Transduction |
| Zdroj: | Cell. 169(1) |
| ISSN: | 1097-4172 |
| Popis: | Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory. |
| Databáze: | OpenAIRE |
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