Extended‐amygdala intrinsic functional connectivity networks: A population study

Autor: Samuel C. Berry, Andrew D. Lawrence, Richard G. Wise, Thomas M. Lancaster
Rok vydání: 2020
Předmět:
Adult
Male
Multifactorial Inheritance
dispositional negativity
extended amygdala (ExtA)
Biology
Amygdala
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Thalamus
Extended amygdala
Neuroimaging
Connectome
task‐free functional magnetic resonance imaging (tf‐fMRI)
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Research Articles
Cerebral Cortex
Human Connectome Project
Radiological and Ultrasound Technology
medicine.diagnostic_test
Central nucleus of the amygdala
Central Amygdaloid Nucleus
05 social sciences
alcohol use
Magnetic Resonance Imaging
Pedigree
Stria terminalis
medicine.anatomical_structure
Neurology
intrinsic functional connectivity (iFC)
Population study
Female
Septal Nuclei
central nucleus of the amygdala (CeA)
Neurology (clinical)
Nerve Net
Anatomy
Functional magnetic resonance imaging
Neuroscience
bed nucleus of the stria terminalis (BST/BNST)
030217 neurology & neurosurgery
Research Article
Zdroj: Human Brain Mapping
ISSN: 1097-0193
1065-9471
Popis: Pre‐clinical and human neuroimaging research implicates the extended‐amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance‐use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised a large sample (n > 1,000 healthy young adult humans) to compare the intrinsic functional connectivity networks (ICNs) of the BST and CeA using task‐free functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. We assessed whether inter‐individual differences within these ICNs were related to two principal components representing negative disposition and alcohol use. Building on recent primate evidence, we tested whether within BST‐CeA intrinsic functional connectivity (iFC) was heritable and further examined co‐heritability with our principal components. We demonstrate the BST and CeA to have discrete, but largely overlapping ICNs similar to previous findings. We found no evidence that within BST—CeA iFC was heritable; however, post hoc analyses found significant BST iFC heritability with the broader superficial and centromedial amygdala regions. There were no significant correlations or co‐heritability associations with our principal components either across the ICNs or for specific BST‐Amygdala iFC. Possible differences in phenotype associations across task‐free, task‐based, and clinical fMRI are discussed, along with suggestions for more causal investigative paradigms that make use of the now well‐established ExtA ICNs.
We examine the intrinsic connectivity networks of two key nodes within the extended amygdala in a large human sample. We find no associations within this network with principal components related to negative disposition or alcohol use traits. We report heritable intrinsic functional connections between the bed nucleus of the stria terminalis (BST) and the centromedial and superficial amygdala regions; however, do not repeat a recent non‐human primate finding of a heritable connection between the BST and central nucleus of the amygdala.
Databáze: OpenAIRE
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