Contribution of coagulation factor VII R353Q polymorphism to the risk of thrombotic disorders development (venous and arterial): A case-control study
| Autor: | Eman Omar Khashaba, Hossam Elwakeel, Nashwa K. Abousamra, Sherif A. Sakr, Reham M. El-farahaty, Ayman Helmy, Hanan Azzam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:QH426-470 Thrombo-embolic risk 030204 cardiovascular system & hematology Gastroenterology AMI 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polymorphism (computer science) Internal medicine hemic and lymphatic diseases Genotype medicine Genetics(clinical) cardiovascular diseases Risk factor Genetics (clinical) lcsh:R5-920 Factor VII business.industry Case-control study medicine.disease Thrombosis Venous thrombosis lcsh:Genetics 030104 developmental biology chemistry FVII R353Q polymorphism Anesthesia Gene polymorphism business lcsh:Medicine (General) DVT |
| Zdroj: | Egyptian Journal of Medical Human Genetics, Vol 18, Iss 3, Pp 275-279 (2017) Egyptian Journal of Medical Human Genetics; Vol 18, No 3 (2017); 275-279 |
| ISSN: | 1110-8630 |
| Popis: | Background Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders. It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele carriers were more associated with lower levels of FVII than R allele carriers. However, the association between coagulation FVII R353 Q polymorphisms and the risk of thrombosis is uncertain. Aim of the study Is to investigate the contribution of factor VII R353Q gene polymorphism to the risk of thrombotic disorders development (venous and arterial) in a group of Egyptian patients. Subjects and methods This study was conducted on 310 subjects: 110 acute myocardial infarction (AMI) patients, 108 deep venous thrombosis (DVT) patients and 92 healthy controls. FVII R353Q genotypes were assessed using restriction fragment length polymorphism analysis. Results There were no statistically significant differences in the frequency of FVII R353Q polymorphism between each of the AMI and DVT patients and the control group (P = 0.9, 0.1). However the Q allele showed a significantly higher frequency in the AMI group (15.4%) vs. controls (8.7%) (OR: 1.92; 95% CI: 0.98–3.7). Bivariate analysis demonstrated no significant association between FVII R353Q genotypes and different studied risk factors, neither in arterial nor venous thrombosis. Conclusion FVII R353Q polymorphism did not contribute to an increased risk of thrombosis (arterial and venous); also carrying the Q allele (of R353Q) did not confer protection against acute thrombotic events. |
| Databáze: | OpenAIRE |
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