Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene
| Autor: | Young-Il Jeong, Yeong-Min Park, Jong-Suk Kim, Hee-ju Park, Chang-Min Lee, In Duk Jung, Sung Nam Park, Jun Sik Lee, Jeong Hyun Chang, Jun-Rim Choi, Il-Whan Choi, Yong Kyoo Shin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Allergy
Eosinophil Peroxidase Ovalbumin Immunology Enzyme-Linked Immunosorbent Assay GATA3 Transcription Factor chemistry.chemical_compound Mice Cell Movement Eosinophilia Immunology and Allergy Medicine Animals Apigenin Lung Asthma Pharmacology Mice Inbred BALB C medicine.diagnostic_test biology business.industry respiratory system Airway obstruction Immunoglobulin E medicine.disease respiratory tract diseases Airway Obstruction Eosinophils medicine.anatomical_structure Bronchoalveolar lavage chemistry Matrix Metalloproteinase 9 biology.protein Cytokines Female Immunization medicine.symptom business Bronchoalveolar Lavage Fluid |
| Zdroj: | International immunopharmacology. 9(7-8) |
| ISSN: | 1878-1705 |
| Popis: | Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties, however the molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma. |
| Databáze: | OpenAIRE |
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