Improved sensitivity of computed tomography towards iodine and gold nanoparticle contrast agents via iterative reconstruction methods
| Autor: | Martina Jurcova, Amar Dhanantwari, Ally Leigh Bernstein, Efrat Shefer, David P. Cormode, Pratap C. Naha, Thomas B. Ivanc, Rabee Cheheltani |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
media_common.quotation_subject Contrast Media 02 engineering and technology Iterative reconstruction Sensitivity and Specificity Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Contrast-to-noise ratio Image Processing Computer-Assisted Medical imaging Image noise Contrast (vision) Sensitivity (control systems) media_common Multidisciplinary business.industry Models Theoretical 021001 nanoscience & nanotechnology Noise Temporal resolution Nanoparticles Gold Tomography X-Ray Computed 0210 nano-technology Nuclear medicine business Iodine Biomedical engineering |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Computed tomography is a widely used medical imaging technique that has high spatial and temporal resolution. Its weakness is its low sensitivity towards contrast media. Iterative reconstruction techniques (ITER) have recently become available, which provide reduced image noise compared with traditional filtered back-projection methods (FBP), which may allow the sensitivity of CT to be improved, however this effect has not been studied in detail. We scanned phantoms containing either an iodine contrast agent or gold nanoparticles. We used a range of tube voltages and currents. We performed reconstruction with FBP, ITER and a novel, iterative, modal-based reconstruction (IMR) algorithm. We found that noise decreased in an algorithm dependent manner (FBP > ITER > IMR) for every scan and that no differences were observed in attenuation rates of the agents. The contrast to noise ratio (CNR) of iodine was highest at 80 kV, whilst the CNR for gold was highest at 140 kV. The CNR of IMR images was almost tenfold higher than that of FBP images. Similar trends were found in dual energy images formed using these algorithms. In conclusion, IMR-based reconstruction techniques will allow contrast agents to be detected with greater sensitivity and may allow lower contrast agent doses to be used. |
| Databáze: | OpenAIRE |
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