Cross-talk of Aryl Hydrocarbon Receptor (AHR)- and Vitamin D Receptor (VDR)-signaling in Human Keratinocytes

Autor:	CHRISTOFOROS CHRISTOFI, LEANDROS LAMNIS, ALEXANDRA STARK, HEIKE PALM, KLAUS RÖMER, THOMAS VOGT, JÖRG REICHRATH
Rok vydání:	2022
Předmět:	Keratinocytes Cancer Research Carcinogenesis General Medicine Vitamins Oncology Calcitriol Receptors Aryl Hydrocarbon Basic Helix-Loop-Helix Transcription Factors Carcinogens Cytochrome P-450 CYP1A1 Humans Receptors Calcitriol Vitamin D Vitamin D3 24-Hydroxylase
Zdroj:	Anticancer research. 42(10)
ISSN:	1791-7530
Popis:	Vitamin D receptor (VDR), activated upon binding of 1,25(OH)Using real-time quantitative PCR, we analyzed in vitro effects of the complete carcinogen UVB and of 1,25(OH)In precancerous HaCaT keratinocytes, induction of a target gene of AHR-mediated transcription (CYP1A1) was markedly stronger after treatment with UVB, as compared to treatment with 1,25(OH)2D3. In contrast, in SCL-1 cells (that reveal the complete phenotype of malignant transformation), expression of CYP1A1 was higher after treatment with 1,25(OH)There is a differential regulation of VDR and AHR target genes by UVB and 1,25(OH)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f8b038ca72d9306e8b3044a6345828 https://pubmed.ncbi.nlm.nih.gov/36191995 Zobrazit plný text záznamu